The energy gluttony of AI, organoid intelligence, 9 simple changes you can make to your prompts to use Large Language Models more sustainably & a great interview by Peter Diamandis with Eric Schmidt
Coincidentally, I am preparing an EU proposal on microplastics effects to the human brain.
We will be using organoids, spheroids, microfluidics, and brain-on-a-chip models + some limited
animal models. We have an "organoid ethics" specialist on board because, this is an actual issue. You have human stem cell derived organoids which are alive and can actually generate electrical pulses and then you zap them with drugs or pollutants. Ethical? Also, we were going to have zebrafish as an animal model because they are so simple that they bypass certain restrictions from animal testing and so often used instead of mouse models.
BTW spheroids also can generate networks of neurons (outside the spheroid) that are active.
I am glad to hear that you have an organoid ethics specialist on board. I'm not sure if it's a requirement for all organizations using organoids, but if it's not, I imagine very few have taken that step. As recearchers (in the link I share about OI) put it the ethical concerns raised by brain organoid research have mainly focused on questions about creating entities that could potentially exhibit consciousness. Could organoids experience pain and, if so, would they suffer – even in rudimentary ways? These concerns will mount during the development of OI, as the organoids become structurally more complex, receive inputs, generate outputs, and – at least theoretically – process information about their environment and build a primitive memory. This will require deeper analysis and research regarding the morally salient neurobiological features that contribute to human capacities, including consciousness, and the implications for OI research and implementation when some or all of these are met. Interesting info about the spheroids.
I look forward to my Monday nights here in Hawaii to see what gems you've come up with that week. Again you educated me and made me think about new stuff. Thanks.
Thanks!
Coincidentally, I am preparing an EU proposal on microplastics effects to the human brain.
We will be using organoids, spheroids, microfluidics, and brain-on-a-chip models + some limited
animal models. We have an "organoid ethics" specialist on board because, this is an actual issue. You have human stem cell derived organoids which are alive and can actually generate electrical pulses and then you zap them with drugs or pollutants. Ethical? Also, we were going to have zebrafish as an animal model because they are so simple that they bypass certain restrictions from animal testing and so often used instead of mouse models.
BTW spheroids also can generate networks of neurons (outside the spheroid) that are active.
Back to writing....
I am glad to hear that you have an organoid ethics specialist on board. I'm not sure if it's a requirement for all organizations using organoids, but if it's not, I imagine very few have taken that step. As recearchers (in the link I share about OI) put it the ethical concerns raised by brain organoid research have mainly focused on questions about creating entities that could potentially exhibit consciousness. Could organoids experience pain and, if so, would they suffer – even in rudimentary ways? These concerns will mount during the development of OI, as the organoids become structurally more complex, receive inputs, generate outputs, and – at least theoretically – process information about their environment and build a primitive memory. This will require deeper analysis and research regarding the morally salient neurobiological features that contribute to human capacities, including consciousness, and the implications for OI research and implementation when some or all of these are met. Interesting info about the spheroids.
I look forward to my Monday nights here in Hawaii to see what gems you've come up with that week. Again you educated me and made me think about new stuff. Thanks.
Thank you so much Houston, likewise (though I am not in Hawaii :-)